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an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
(2013) AACR poster 491
NVP-231 (0-500 nM
28(5):457-463
CAS Number: 29767-20-2
Ivacaftor (benzenesulfonate) Catalog No.:M9558-2 an inhibitor of BET transcriptionalVX 770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 45% cases of cystic fibrosis, and is included in a combination drug, lumacaftor ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR. Ivacaftor is a "potentiator" of CFTR, meaning it increases the probability that the defective channel
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