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also known as Mutant EGFR inhibitor
PF-04880594 Catalog No.:M22519-C also known as Mutant EGFRPF 04880594 is a selective inhibitor of B Raf, B RafV599E and c Raf with IC50 value of 0. 19 nM, 0. 13 nM and 0. 39 nM, respectively . Raf is a serine threonine protein kinase and plays an important role in the MAPK ERK signaling pathway. It has been revealed that Raf involves in cancers and developmental syndromes and its inhibitors are regarded as a promising target for cancer treatment [2, 3]. PF 04880594 is a potent Raf inhibitor. When tested with
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