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Since it lets you cast a permanent with a mana value two or less from your graveyard, you can continuously use cards that need to sacrifice themselves to trigger

This sort of interaction was enough to earn Hullbreacher and Leovold, Emissary of Trest spots on the Commander ban list

Its also the only card with the grandchild creature type

Paying a single green mana to dump your entire deck into your graveyard (assuming you dont run basics) enables a bunch of busted combos

When it comes to any singles that you could potentially find at an LGS

If you sacrifice Chalice of the Void as a cost to cast a spell, its ability can't trigger