The obvious downside is, of course, the opponent chooses which cards are destroyed, so they can select cards they may very well want to be destroyed - though Grinning Grave Virus does at least prevent graveyard effects for one turn
From Maze of Ith to Swords to Plowshares, folks will be taking damage all over the place
We won't likely win on turn five, but we should be applying a lot of pressure early on
If the controller gains LP while they control Number 43: Manipulator of Souls, they can use its effect to increase its ATK by the same amount, and also inflict that amount as damage to the opponent
This way you can use the below tier list to figure out which booster packs you wish to target or get an idea on what you can do with your current card collection
Assault Sonic Warrior Level 2 WIND You can only use each of the [1] [2] effects of this card once per turn