ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 ethyltransferase Chemical Name: 4-(4-(5

Chemical Name: 4-(4-(5

DAPT is used at 10 µM final concentration in cell culture

CAS Number: 1380548-02-6

4-d]pyrimidin-3-one

Smiles: C[C@H](NC(=O)C1=CC2=C(C=C1)N(CC1C=CC(=CC=1)C1=CC=CC=C1C(O)=O)C(C)=C2C)C1C=CC(=CC=1)[N+]([O-])=O

ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 ethyltransferase Chemical Name: 4-(4-(5ISRIB (trans isomer), CAS No. 1597403 47 8, is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2 phosphorylation (IC50=5 nM). In cells, distinct stress conditions activate different downstream kinases, including PERK, that converge on phosphorylating the subunit of initiation factor 2 (eIF2 ). This collection of signaling pathways is termed the integrated stress response (ISR). Trans ISRIB is a potent and