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CCT251545 potently inhibits WNT pathway activity in COLO205-F1756 clone 4 (an APC -mutant human colorectal cancer cell line engineered to express a modified luciferase-based WNT reporter construct) with an IC50 of 0
Smiles: CN1C(NC2=CC=C(I)C=C2F)=C2C(=C(C)C1=O)N(C1=CC(=CC=C1)NC(C)=O)C(=O)N(C1CC1)C2=O
Right now it is in phase I clinical trials for patients with refractory advanced solid tumors
CAS Number: 2169266-64-0
as compared with 0
ME-401 lC3-acid CCT251545 potently inhibits WNT pathwayME 401(PWT 143) is a potent and selective inhibitor of P110 with IC50 of 8. 4 nM. Product information CAS Number: 1595129 71 7 Molecular Weight: 604. 77 Formula: C31H40N8O3S Synonym: PWT 143 P110 IN 1 Chemical Name: N (2 methyl 1 (2 (1 methylpiperidin 4 yl)phenyl)propan 2 yl) 4 (2 (methylsulfonyl) 1H benzo[d]imidazol 1 yl) 6 morpholino 1,3,5 triazin 2 amine Smiles: CN1CCC(CC1)C1=CC=CC=C1CC(C)(C)NC1=NC(=NC(=N1)N1C(=NC2=CC=CC=C12)S(C)(=O)=O)N1CCOCC1
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