NMS-1286937 Catalog No.:M9125-10 4-f]isochromene-3

4-f]isochromene-3

InChi: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1

CTEP Derivative fully displaces [3H]-MPEP with a Ki of 35

⁸]tetradecan-6-yl 2-({1-[(2R)-2-amino-3-methylbutanamido]-2-methylpropan-2-yl}sulfanyl)acetate hydrochloride

5-dihydroxy-6-(hydroxymethyl)-3-{[(2S

NMS-1286937 Catalog No.:M9125-10 4-f]isochromene-3Onvansertib, also know as NMS P937, PCM 075 and NMS1286937, is a n orally bioavailable, small molecule Polo like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo like kinase 1 inhibitor NMS 1286937 selectively inhibits PLK1, inducing selective G2 M cell cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1