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Doramapimod Catalog No.:M10899-2 sequence analysis and functional characterization

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Description

sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs

InChi: InChI=1S/C22H26N2O7/c25-17-12-11-15(20(28)23-17)24-21(29)14-8-7-9-16(19(14)22(24)30)31-13-6-4-2-1-3-5-10-18(26)27/h7-9

InChiKey: OCRYFLKYXNBUEY-UHFFFAOYSA-N

SGC707 was used at 5-10 µM final concentration in various in vitro assays

PMCID: PMC6794838

Doramapimod Catalog No.:M10899-2 sequence analysis and functional characterizationDoramapimod, also known as BIRB 796, is a member of the N pyrazole N' naphthly urea class of p38MAPK inhibitors, which binds to the kinase with both slow association and dissociation rates. BIRB 796 has entered clinical trials for the treatment of autoimmune diseases. Product information CAS Number: 285983 48 4 Molecular Weight: 527. 66 Formula: C31H37N5O3 Chemical Name: 3 [3 tert butyl 1 (4 methylphenyl) 1H pyrazol 5 yl] 1 {4 [2 (morpholin 4

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