OTSSP167 - CAS# 1431697-89-0 D 169316 shows weaker inhibition of EGFR

shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 µM) and JAK2 (50 µM)

1-2H3/b8-5+/t14-

HS Tariff Code: 38200

beginning at less than micromolar concentrations

Formula: C17H23NO

OTSSP167 - CAS# 1431697-89-0 D 169316 shows weaker inhibition of EGFROTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK expressing tumor cells. Product information CAS