8-CPT-Cyclic AMP (sodium salt) LKGGAPIKGV-EDDNP TFA 4]thiadiazole

4]thiadiazole

c-Met-R988C

genetic and cell biology data point to Dyrk1a as the key molecular target

16-hexaen-20-ide iminomethanide

H2O/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20

8-CPT-Cyclic AMP (sodium salt) LKGGAPIKGV-EDDNP TFA 4]thiadiazoleKa : 0. 05 and 0. 11 M for PKA and PKG, respectively 8 CPT Cyclic AMP is a lipophilic activator of the cyclic AMP and cyclic GMP dependent protein kinases, PKA and PKG. The ability of cGMP dependent protein kinases (cGKs) to activate cAMP response element (CRE) dependent gene transcription was compared with that of cAMP dependent protein kinases (cAKs). In vitro: A previous study found that 8 CPT Cyclic AMP was a potent activator of cAMP PK and cyclic