Linopirdine Catalog No.:M26286-C 5-HT1 or 5-HT2 or cholinergic-muscarinic

5-HT1 or 5-HT2 or cholinergic-muscarinic sites with IC50 values less than 1 μM

C2HF3O2/c1-9-83(4)129(221-220-116(69-92-74-190-97-38-20-19-37-95(92)97)154(261)211-112(70-93-75-183-81-196-93)152(259)213-115(73-127(238)239)139(246)194-79-122(231)199-106(52-55-125(234)235)147(254)210-110(67-89-33-15-11-16-34-89)138(245)195-80-124(233)217-132(87(8)224)158(265)266)156(263)208-108(53-56-126(236)237)149(256)209-109(66-88-31-13-10-14-32-88)133(240)134(241)130(85(6)222)219-135(242)84(5)197-150(257)113(71-118(169)227)212-151(258)111(68-90-35-17-12-18-36-90)214-155(262)128(82(2)3)218-153(260)114(72-119(170)228)215-157(264)131(86(7)223)216-123(232)77-191-120(229)76-193-137(244)98(41-25-59-184-159(171)172)200-143(250)102(43-27-61-186-161(175)176)204-145(252)104(45-29-63-188-163(179)180)206-148(255)107(51-54-117(168)226)207-146(253)105(46-30-64-189-164(181)182)205-144(251)103(44-28-62-187-162(177)178)203-142(249)101(40-22-24-58-166)202-141(248)100(39-21-23-57-165)201-140(247)99(42-26-60-185-160(173)174)198-121(230)78-192-136(243)96(167)65-91-47-49-94(225)50-48-91

which act on the Ca2+-signaling pathway including CaN activation

BFH772 inhibits the ligand induced autophosphorylation of RET

InChi: InChI=1S/C12H14O5/c1-3-17-11(16)5-8-4-9(14)6-10(15)12(8)7(2)13/h4

Linopirdine Catalog No.:M26286-C 5-HT1 or 5-HT2 or cholinergic-muscarinicLinopirdine (DuP 996) is an orally active, selective M type K+ current (IM; Kv7; KCNQ Channels) inhibitor with an IC50 of 2. 4 M. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing drug, increases acetylcholine release in rat brain tissue. Product information CAS Number: 105431 72 9 Molecular Weight: 391. 46 Formula: C26H21N3O Chemical Name: 1 phenyl 3,3 bis[(pyridin 4 yl)methyl] 2,3 dihydro 1H indol 2 one Smiles: