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Smiles: CN1N=C(C=C1C1=CC=C(OCC2C=CC(Cl)=CC=2)C(=C1O)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C(F)(F)F
Increased production of vasoconstrictive prostanoids
20)3/h15-21
whereas it is inactive in these conditions in PC3 cells at concentrations up to 10 μM
Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy
MAGL-IN-1 444296 Smiles: CN1N=C(C=C1C1=CC=C(OCC2C=CC(Cl)=CC=2)C(=C1O)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C(F)(F)FMAGL IN 1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL IN 1 exhibits anti proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL IN 1 blocks MAGL in cell based as well as in vivo assays. Product information CAS Number: 2324160 91 8 Molecular Weight: 369. 43 Formula: C22H24FNO3 Chemical Name: 4 fluoro 3 {4 [4 (propan 2 yl)benzoyl]piperidine 1 carbonyl}phenol Smiles:
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