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(ii) Occurrence of changes in drug metabolism pathways, especially in relation to aromatic anticonvulsants, and (iii) Reactivation of viruses from the Herpesviridae family, particularly Human Herpes Virus 6 (HHV6), which leads to a T lymphocyte-mediated inflammatory response that results in varied tissue damage.11 HLA system HLA alleles constitute one of the most relevant risk factors for the development of DRESS

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