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1883429-21-7
Chemical Name: (E)-N'-(1-(pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide
Product information
1245537-68-1
Cilliobrevin D was used at 20-50 μM concentration in the in vitro assays
AG-120 (Ivosidenib) - IDH1 Inhibitor. CAS# 1448347-49-6 Catalog No.:M60318-10S 1883429-21-7AG 120 (Ivosidenib), CAS No. 1448347 49 6, is a potent, selective and reversible inhibitor of IDH1 with IC50 < 100 nM. It has been shown to lower 2 HG levels and restore cellular differentiation in IDH1 mutant primary human blast cells cultured ex vivo. In phase I clinical trials targeting patients with IDH1 mutated, relapsed and or refractory (R R) AML or untreated AML not eligible for standard of care or R R MDS, AG 120 is well tolerated to date (10
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