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Deltarasin was used at 5 µM final concentration in various in vitro assays
LY294002 could be dosed to the mice by IP administration at 100 mg/kg once day
Chemical Name: (S)-2-((2R
especially HDACs
PYZD-4409 was dosed intraperitoneally to the mouse model of leukemia (MDAY-D2 murine leukemia cells) at 10 mg/kg once per day
PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 Catalog No.:M60201-10S Deltarasin was used at 5PYR 41, CAS No. 418805 02 4, is a ubiquitin activating enzyme inhibitor (UBE1 inhibitor). PYR 41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high MW ubiquitinated proteins. PYR 41 also mediated cross linking of specific protein kinases (Bcr Abl, Jak2) to inhibit their signaling activity. PYR 41 has demonstrated anti tumor activity in animal studies, partially selective protein cross linking may represent an alternate
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