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Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) inhibits MELK (IC50=38 nM)
InChiKey: HQUPLSLYZHKKQT-WVVFQGGUSA-N
InChi: InChI=1S/C32H38N4O2/c1-24(37)35-20-14-28-10-11-30(22-31(28)35)36(32(38)12-9-26-7-4-8-27(21-26)23-33)29-15-18-34(19-16-29)17-13-25-5-2-3-6-25/h4
activating caspase
with IC50s of 9
LP-533401 Size:Contact [email protected] for quotation Prexasertib Mesylate Hydrate (LY2606368 MesylateLP 533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut. LP 533401 completely inhibits serotonin production in Tph1expressing cells (RBL2H3 cells) at a dose of 1 M. Oral administration once daily for up to 6 weeks of this small molecule prevents the development of and fully rescues, in a dose dependent manner, osteoporosis in ovariectomized rodents because of an isolated increase in bone formation.