G-36 8100 KYA1797K can effectively suppress the

KYA1797K can effectively suppress the growth of CRCs harboring APC and KRAS mutations

5R)-5-((((((((((2R

CNC(=O)C1=CC=CC=C1NC1=NC(NC2=CC=C(C=C2)N2CCNCC2)=NC=C1Cl

InChi: InChI=1S/C14H16O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-6

PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells

G-36 8100 KYA1797K can effectively suppress theG protein coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man made estrogens. It is thought to be involved in estrogen sensitive cancers., GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth. G 36 is a cell permeable non steroidal antagonist of GPER, inhibiting activation by either 17 estradiol or the GPER selective agonist G 1 (IC50 = 112 and 165 nM,