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with potential clinical and research applications in nontransgenic animals
Formula: C15H13N3S
20)/t11-/m1/s1
Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors
In vitro and in vivo chemosensitizing activity of LFM-A13
KU-60019 B018304 with potential clinical and researchKU 60019 is a potent and selective ATM inhibitor. KU 60019 is 10 fold more effective than KU 55933 at blocking radiation induced phosphorylation of key ATM targets in human glioma cells. As expected, KU 60019 is a highly effective radiosensitizer of human glioma cells. KU 60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells