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Pexmetinib (0
3-thiazol-2-yl)-4-methylpentan-3-yl](methyl)carbamoyl}-1-hydrogenio-2-methylbutyl]carbamoyl}-1-({4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-[6-(2
but has no affinity for µ-
CAS Number: 1360540-81-3
CN1C(=O)C(=C(N=C1NCC(N)CC1C=CC=CC=1)C1C=CN=CC=1)C1=CC2=CC=CC=C2C=C1
ATX inhibitor 5 20529 Pexmetinib (0ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15. 3 nM. ATX inhibitor 5 shows anti hepatofibrosis effects and reduces CCl4 induced hepatic fibrosis level prominently. Product information CAS Number: 2402772 45 4 Molecular Weight: 474. 87 Formula: C22H18ClF3N6O Chemical Name: N' [(1E) (4 chlorophenyl)methylidene] 4 {[3 (trifluoromethyl)phenyl]amino} 5H,6H,7H,8H pyrido[4,3 d]pyrimidine 6 carbohydrazide Smiles:
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