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also known as SC-69124A and Dynastat
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
Maksim V Kvach
von Samson-Himmelstjerna G
An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6
D-Cycloserine Catalog No.:M10601-10 also known as SC-69124A andAlobresib, also known as GS 5829, is a potent and selective BET inhibitor. GS 5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment. GS 5829 inhibited CLL cell proliferation and induced leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1 2, and MYC. IB modulation indicates that GS 5829 also inhibited NF B signaling. GS 5829 induced apoptosis resulted from an imbalance between
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