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LDN-57444 - Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor. CAS# 668467-91-2 Catalog No.:M60204-10S Preclinical modeling of combined phosphatidylinositol-3-kinase

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Description

Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer

1216665-49-4

Conversely

Chemical Name: N-((4

promoting erythropoiesis or preventing anemia in vivo

LDN-57444 - Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor. CAS# 668467-91-2 Catalog No.:M60204-10S Preclinical modeling of combined phosphatidylinositol-3-kinaseLDN 57444, CAS No. 668467 91 2, is a novel potent and selective inhibitor of ubiquitin C terminal hydrolase L1 (UCH L1) with IC50 ~0. 88 M. It has ~28 fold greater selectivity over UCH L3 (ubiquitin C terminal hydrolase L3). LDN 57444 can increase levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. It causes cell death through the apoptosis pathway. LDN 57444s activity leads to dramatic alterations in synaptic protein

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