SR9011 - REV-ERB Agonist. CAS# 1379686-29-9 Catalog No.:M66049-2S InChi: InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10

InChi: InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10

SCHEMBL1316601

The affinity of Eptapirone (F11440) for 5-HT1Abinding sites (pKi

It is used in a chemical cocktail of seven small molecules to directly convert human fibroblasts into neuronal cells bypassing a neural progenitor stage

Pre-treatment of AML cells with IPI-145 inhibits both adhesion and migration of AML blasts to bone marrow stromal cells

SR9011 - REV-ERB Agonist. CAS# 1379686-29-9 Catalog No.:M66049-2S InChi: InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10SR9011, CAS No. 1379686 29 9, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~790 nM and REV ERB with EC50 ~560 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock