ASK1-IN-1 I-1867 The observed single agent antitumor

The observed single agent antitumor activity in heavily pretreated CRC patients was limited

Formula: C14H8O9

thus far perceived to be “undruggable

22(6):825-37

S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver

ASK1-IN-1 I-1867 The observed single agent antitumorASK1 IN 1 is a CNS penetrant ASK1 (apoptosis signal regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM). Product information CAS Number: 2411382 24 4 Molecular Weight: 405. 41 Formula: C19H19N9O2 Chemical Name: 4 (4 cyclopropyl 1H imidazol 1 yl) N [3 (4 cyclopropyl 4H 1,2,4 triazol 3 yl)phenyl]pyridine 2 carboxamide Smiles: COC1=NN(C=C1C(=O)NC1=CC=CC(=N1)C1=NN=CN1C(C)C)C1=CN=CC=N1 InChiKey: FTPVMITWJIXRGQ