NB-360 Size:Contact [email protected] for quotation N[C@@H](CCCCNCC(=O)C1=CC=CO1)C(O)=O

N[C@@H](CCCCNCC(=O)C1=CC=CO1)C(O)=O

Solubility: DMSO : ≥ 32 mg/mL (88

Formula: C16H26N4O9

and brain penetrating T-type calcium channel blocker

CAS Number: 60-27-5

NB-360 Size:Contact [email protected] for quotation N[C@@H](CCCCNCC(=O)C1=CC=CO1)C(O)=ONB 360 is a potent, brain penetrable, and orally bioavailable dual BACE1 BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB 360 shows a superior pharmacological profile and robust reduction of amyloid and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB 360 can completely block the progression of A deposition in the brains of APP transgenic mice. NB 360 shows excellent selectivity over the related aspartyl