Itraconazole-d5 oxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside is a cAMP-specific PDE inhibitor

is a cAMP-specific PDE inhibitor with an IC50 of 10

CAS Number: 202471-84-9

50(11):579-85

294(18):7377-7387

ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14

Itraconazole-d5 oxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside is a cAMP-specific PDE inhibitorItraconazole d5 (R51211 d5) is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14 demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Product information CAS