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17-dimethoxy-21-[2-(methylamino)ethyl]-5
6)/b2*5-2+
Smiles: CC1C=C(N(N=1)C1C=CC=CC=1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CSCC1
N-Allylthiourea
which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor
AVN-944 fil dihydrochloride 17-dimethoxy-21-[2-(methylamino)ethyl]-5AVN 944 (VX 944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of