2', 3', 5'-triacetyl-5-Azacytidine Size:Contact [email protected] for quotation Smiles: COC1=CC(Br)=C(C=C1OC)S(=O)(=O)NC1=CC(O[C@H]2CN(C)CC2)=C(Cl)C=C1

Smiles: COC1=CC(Br)=C(C=C1OC)S(=O)(=O)NC1=CC(O[C@H]2CN(C)CC2)=C(Cl)C=C1

The pharmacokinetics of MK-3903 (compound 42) in C57BL/6 mice

Nutlin-3a effectively depletes the S-phase compartment to 0

ClH/c1-11(2)10-14(17)15(8-3-9-15)12-4-6-13(16)7-5-12

without animal death and <10% weight loss

2', 3', 5'-triacetyl-5-Azacytidine Size:Contact [email protected] for quotation Smiles: COC1=CC(Br)=C(C=C1OC)S(=O)(=O)NC1=CC(O[C@H]2CN(C)CC2)=C(Cl)C=C12',3',5' triacetyl 5 Azacytidine (TAC) is the lead prodrug form of 5 azacytidine which may be rapidly absorbed after oral administration . 5 Azacytidine is an inhibitor of DNA methyltransferase . The DNA methyltransferase belongs to a family of enzymes involved in catalyzing the transfer of a methyl group to DNA. DNA methylation has been implicated in regulating gene expression in normal and malignant cells . In vivo: In CD 1 mice, oral administration