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As none of the Ishizu monsters have any relevant effects on the field, you can safely trade them over for even more impressive monsters from your opponent's side

According to official Play

Instant Color tag templates(None) Golgari Charm Choose one All creatures get -1/-1 until end of turn

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But in any other case, when you're not destroying a Cabal Coffers or Field of the Dead level card, you're spending a decent chunk of mana to deal with something that there are better answers to deal with