CX-5461 dihydrochloride Catalog No.:M14526-2 Smiles: COC1=CC=CC=C1NC(=O)C(CC)SC1=NC2=C(N=N1)C1=CC=CC=C1N2CC

Smiles: COC1=CC=CC=C1NC(=O)C(CC)SC1=NC2=C(N=N1)C1=CC=CC=C1N2CC

3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide dihydrochloride

Filippo Spriano

21(8-9):1104-9

Liensinine

CX-5461 dihydrochloride Catalog No.:M14526-2 Smiles: COC1=CC=CC=C1NC(=O)C(CC)SC1=NC2=C(N=N1)C1=CC=CC=C1N2CCCX 5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I mediated rRNA synthesis, with IC50s of 142 nM in HCT 116, 113 nM in A375, and 54 nM in MIA PaCa 2 cells, and shows little or no effect on Pol II (IC50 25 M). Product information Molecular Weight: 586. 54 Formula: C27H29Cl2N7O2S Chemical Name: 4 (4 methyl 1,4 diazepan 1 yl) N [(5 methylpyrazin 2 yl)methyl] 8 oxo 11 thia 1,3 diazatetracyclo[8. 7. 0. 0,. 0,]heptadeca