Pay in 4 interest-free payments of $14.50 Learn more
Ships within 48 hours · Estimated delivery Jul 30 - Aug 4
185(1):634-41
4 μM for KDM4A and 9
quickly equilibrating with the central nervous system
7R)-7-hydroxy-5-methyl-6
MOA study showed P7C3 could bind nicotinamide phosphoribosyltransferase (NAMPT)
EPZ-5676 - DOT1L inhibitor. CAS# 1380288-87-8 60160 185(1):634-41EPZ 5676, CAS No. 1380288 87 8, is a highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S adenosylmethionine. It inhibits proliferation of MLL AF4 rearranged cell line MV4 11 with an IC50 of 9 nM. It reduces H3K79 dimethylation with a cellular IC50 of 2. 6 nM in MV4 11 cells. EPZ 5676 has over 10, 000 fold selectivity against other HMTs. Its superior potency is
US$ 119.50
US$ 111.20
US$ 125.00
US$ 199.20
US$ 127.20
US$ 179.00
US$ 189.00
US$ 11.00
US$ 159.60
US$ 15.00
US$ 175.20