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InChi: InChI=1S/C31H34O14/c1-28-13-30(38)20-11-31(28
CAS Number: 12672-45-6
InChiKey: IUKLSMSEHKDIIP-BZMYINFQSA-N
Soyasaponin IV
but shows no obvious effect on inositol phosphate-1 formation induced by BK (3 nM) activation of B2 receptor in human fibroblast MRC5
EN6 HIBO InChi: InChI=1S/C31H34O14/c1-28-13-30(38)20-11-31(28EN6 is a small molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v ATPase). EN6 mediated ATP6V1A modification decouples the v ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP 43 aggregates, a causative agent in frontotemporal dementia, in a lysosome dependent manner.
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