Isoginkgetin ker Conjugates 3 BTK inhibitor 18 (Compound 27)

BTK inhibitor 18 (Compound 27) also inhibits BMX

InChi: InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6

Chemical Name: (3R)-1-{2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzoyl}piperidin-3-ol

InChiKey: JQRZBPFGBRIWSN-YOTVLOEGSA-N

InChi: InChI=1S/C16H23NO5

Isoginkgetin ker Conjugates 3 BTK inhibitor 18 (Compound 27)Isoginkgetin is a MMP 9 inhibitor, also a Pre mRNA Splicing Inhibitor with IC 50 of 30 uM. target : MMP 9 , Pre mRNA Splicing IC 50: 30 u M (Pre mRNA Splicing)In vitro: Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin is also quite effective in inhibiting the activities of Akt and MMP 9 in MDA MB 231 breast carcinomas and B16F10 melanoma. Isoginkgetin treatment result in marked decrease in invasion of these cells.