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It inhibits IDH1 R132H mutant and R132C mutant in vitro with IC50 ~0
0 μM in cells
CAS Number: 476-66-4
InChi: InChI=1S/2C13H13N3O3
12-pentaoxatricyclo[7
LCL161 Size:Solid 10 mg It inhibits IDH1 R132H mutantLCL161 is a n orally bioavailable second mitochondrial derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic
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